Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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If drugs are withdrawn, recurrence of symptoms may not become apparent for several weeks or months. Because paxkage fluphenazine and lithium have been associated with QT prolongation, coadminister cautiously and decanoatd close monitoring. There is an increased risk of morbidity and mortality in elderly patients treated with antipsychotics for dementia-related psychosis. Subcutaneous injection fluphenazine decanoate or fluphenazine enanthate: Moderate Coadministration of dexmedetomidine with phenothiazines to lead to an enhancement of anesthetic, sedative, or cardiovascular effects.

Conversely, if inssrt stop tobacco smoking, the dosage of the phenothiazine may need to be reduced. Minor Due to an increased risk for QT prolongation and torsade de pointes TdPcaution is advised when administering fluphenazine with gemifloxacin.

Belladonna Alkaloids; Ergotamine; Phenobarbital: Minor Use caution if fluphenazine is administered with encorafenib.

If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment. Phenothiazines, like fluphenazine, should be used cautiously in patients with significant cardiac disease or pulmonary disease.

Anxiolytics; Sedatives; and Hypnotics: Minor Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering fluconazole with fluphenazine.


fluphenazine decanoate

Major COMT inhibitors should be given cautiously with other agents that cause CNS depression, including phenothiazines, due to the possibility of additive sedation. Moderate Iloperidone has been associated with QT prolongation; however, torsade de pointes TdP has not been reported. Major Carefully consider the need for concomitant treatment with phenothiazines and amifampridine, as coadministration may increase the risk of seizures.

For flupehnazine information, contact the registry at https: Inhibits metabolism and increases toxicity of these drugs. Acetaminophen; Butalbital; Caffeine; Codeine: Ethanol ingestion may further impair cognitive and motor skills and patients should be advised to avoid use of alcoholic beverages. Avoid spilling the solution on the skin and clothing. Slight yellow to amber color does not alter fluphenazien.

Minor Citalopram causes dose-dependent QT interval prolongation. It may not oackage until months or years later and may disappear spontaneously or persist for life, despite ending drug. Minor Due to a possible risk for QT prolongation and torsade de pointes TdPgranisetron and fluphenazine should be used together cautiously. Moderate Phenothiazines are CNS depressant drugs that may have cumulative effects when administered concurrently and they should be used cautiously with anxiolytic, sedative, and hypnotic type drugs, such insfrt the benzodiazepines.

Clinicians should be aware that increased dosage requirements may occur in some tobacco smokers.

Limited in vivo data suggest that clobazam is an inhibitor of CYP2D6. Patients without previous exposure to a depot fluphenazine formulation: In clinical trials, QT prolongation has been dceanoate in patients who received midostaurin as single-agent therapy or in combination with cytarabine and daunorubicin.

The need to coadminister methadone with drugs known to prolong the QT interval should be done with extreme caution and a careful assessment of treatment risks versus benefits. Minor Due to a possible risk for QT prolongation and torsade de pointes TdPdasatinib and fluphenazine should be used together cautiously. This site uses cookies.


Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as diphenhydramine, a sedating H1-blocker. Phenothiazines may impair body temperature regulation.

Modecate Injection 25mg/ml

Tardive dyskinesia is a syndrome of potentially irreversible, involuntary, dyskinetic movements that may develop in patients treated with antipsychotics.

Marketing authorisation number s 9. Kava Kava, Piper methysticum: Minor Consider periodic monitoring of EGCs for QT prolongation and monitor electrolytes if coadministration of histrelin and fluphenazine is necessary; correct any electrolyte abnormalities. However, melatonin co-administration resulted in increased feelings of cognitive impairment compared to thioridazine alone.

Data collected from the Swedish Medical Birth Registry showed an increased risk of major malformations e. Adverse effects such as extrapyramidal symptoms, agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, pacoage feeding disorder have been reported after delivery in neonates exposed to antipsychotics during the third trimester.

Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Prior to concurrent use of buprenorphine in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient’s overall response to fpuphenazine.

Solution for Injection Pale yellow clear, oily liquid.